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Lori
02-15-2007, 09:13 AM
I'm just so horrified by this. Taking mental illness seriously is one thing, but prescribing a toddler these kinds of drugs is just absolutely insane.

http://www.nytimes.com/2007/02/15/us/15bipolar.html?hp&ex=1171602000&en=8c9cf594e7bae322&ei=5094&partner=homepage

Debate Over Children and Psychiatric Drugs
By BENEDICT CAREY
Early on the morning of Dec. 13, police officers responding to a 911 call arrived at a house in Hull, Mass., a seaside town near Boston, and found a 4-year-old girl on the floor of her parents’ bedroom, dead.

She was lying on her side, in a pink diaper, the police said, sprawled across some discarded magazines and a stuffed brown bear.

Last week, prosecutors in Plymouth County charged the parents, Michael and Carolyn Riley, with deliberately poisoning their daughter Rebecca by giving her overdoses of prescription drugs to sedate her.

The police said the girl had been taking a potent cocktail of psychiatric drugs since age 2, when she was given a diagnosis of attention deficit disorder and bipolar disorder, which is characterized by mood swings.

The parents have pleaded not guilty, with their lawyers questioning whether the child should have been prescribed such powerful drugs.

The case has shaken a region known for the excellence of its social and medical services. The director of the state’s Department of Social Services has had to defend his agency, which had been investigating the case before the girl’s death.

The girl’s treating psychiatrist has taken a voluntary, paid leave until the case is resolved. And New Englanders are raising questions that are now hotly debated within psychiatry, and which have broad implications for how young children like Rebecca Riley are cared for.

Tufts-New England Medical Center, where the child was treated, released a statement supporting its doctor and calling the care “appropriate and within responsible professional standards.”

Indeed, the practice of aggressive drug treatment for young children labeled bipolar has become common across the country. In just the last decade, the rate of bipolar diagnosis in children under 13 has increased almost sevenfold, according to a study based on hospital discharge records. And a typical treatment includes multiple medications.

Rebecca was taking Seroquel, an antipsychotic drug; Depakote, an equally powerful mood medication; and Clonidine, a blood pressure drug often prescribed to calm children.

The rising rates of diagnosis and medication use strike some doctors and advocates for patients as a dangerous fad that exposes ever-younger children to powerful drugs. Antipsychotics like Seroquel or Risperdal, which are commonly prescribed for bipolar disorder, can cause weight gain and changes in blood sugar — risk factors for diabetes.

Some child psychiatrists say bipolar disorder has become an all-purpose label for aggression.

“Bipolar is absolutely being overdiagnosed in children, and the major downside is that people then think they have a solution and are not amenable to listening to alternatives,” which may not include drugs, said Dr. Gabrielle Carlson, a professor of psychiatry and pediatrics at Stony Brook University School of Medicine on Long Island.

Paraphrasing H. L. Mencken, Dr. Carlson added, “Every serious problem has an easy solution that is usually wrong.”

Others disagree, insisting that increased awareness of bipolar disorder and use of some medications has benefited many children.

“The first thing to say is that the world does not see the kids we see; these are very difficult patients,” said Dr. John T. Walkup, a child and adolescent psychiatrist at the Johns Hopkins University School of Medicine.

Dr. Walkup said that when drug treatment was done right, it could turn around the life of a child with a diagnosis of bipolar disorder.

Dr. Jean Frazier, director of child psychopharmacology at Cambridge Health Alliance and an associate professor at Harvard, said that up to three-quarters of children who exhibit bipolar symptoms become suicidal, and that it is important to treat the problem as early as possible.

“We’re talking about a serious illness with high morbidity, and mortality,” Dr. Frazier said, “and for some of these children the medications can be life-giving.”

Still, most child psychiatrists agree that there are still questions about applying the diagnosis to very young children. Recent research has found that most children who receive the diagnosis are emotionally explosive but do not go on to develop the classic features of the disorder, like euphoria. They are far more likely to become depressed.

And many therapists have found that some patients referred to them for bipolar disorder are actually suffering from something else.

“Most of the patients I see who have been misdiagnosed have been told they have bipolar disorder,” said Dr. Bessel van der Kolk, a professor of psychiatry at Boston University who runs a trauma clinic.

“The diagnosis is made with no understanding of the context of their life,” Dr. van der Kolk said. “Then they’re put on these devastating medications and condemned to a life as a psychiatry patient.”

Details about what happened to Rebecca are still emerging. A relative of her mother, Carolyn Riley, 32, told the police that Rebecca seemed “sleepy and drugged” most days, according to the charging documents.

One preschool teacher said that at about 2 p.m. every day the girl came to life, “as if the medication Rebecca was on was wearing off,” according to the documents.

Defense lawyers are also focusing on the question of medication. “What I want to know,” said John Darrell, a lawyer for Mr. Riley, “is how in the world you diagnose a 2-year-old and give her these strong medicines that are not approved for children.”

A lawyer for Rebecca’s psychiatrist, Dr. Kayoko Kifuji of Tufts-New England Medical Center, did not return calls seeking comment.

Some experts say the temptation to medicate can be powerful.

“Parents very often want a quick fix,” Dr. Carlson said, “and doctors rarely have much time to spend with them, and the great appeal of prescribing a medication is that it’s simple.

“To me one of the miracle of children’s brains is that we don’t see more harm from these treatments.”

Val
02-15-2007, 10:37 AM
This is something that infuriates me. Cold medicine isn't tested for kids this young. But by all means, let's give them haldol or some other nonsense. Not to mention how one goes about identifying bipolar dissorder in a toddler- when they are by deffinition crazy little beings. I have more to say but I'm about to time out......

Val
02-15-2007, 10:44 AM
I can't really put the rest into words very well. Toddler mood swings are well known- on moment they're throwing a fit and the next they're the happiest kid in the world when they get a lollipop. Bipolar disorder has the swings between manic and depressive (for some reason I think it's atleast 3 a year) and I just don't see how a 2 year old can elaborate for you to tell a manic episode from a typical toddler moment like you could with an adult. When someone comes to me and says they're investing their life savings in a tropical bird farm located on the North Pole- I can call that crazy. But when a 2 year old gets the grand idea that they can fly- I can't label that as crazy because of their age and inability to comprehend the world around them.

Jo
02-15-2007, 11:07 AM
Using meds off label can be life giving for some children. Rai has been on and off meds her whole life that were off label at the time. She is alive because of it. But I do question how often mood and anti psychotic medications are being used in children. How can they possibly know at 2 what the accurate diagnosis is?

There is also the issue of how different the brains of young children are. They aren't tiny adult brains. They are growing and learning and forming pathways faster at that age then they ever will in the future. I do wonder how interfering with that process through medication affects them.

Lori
02-15-2007, 11:14 AM
I also can't figure out how they could determine if a two-year-old has a psychiatric disorder. That's a diagnosis that will stay with the child for life, and the line between normal two-year-old behavior and pathological two-year-old behavior is so thin that I really would be hesitant to accept that sort of diagnosis, particulary when the treatment involved such powerful drugs.

In this case, it's hard for me to see how the benefit of putting the child on these drugs can outweigh the risks. I realize that the suicide rates in bipolar disorder are high, and that needs to be considered, but the suicide rates among children with bipolar disorder certainly aren't high, and it seems like the risks of putting them on such powerful medications so young far outweighs the benefits. Why not wait a few more years to get an accurate diagnosis, and then worry about how to proceed medication-wise at that point? At two or four, the child may have very troubling behavior, but they are not going to be posing a serious risk to themselves, to the point where using these drugs could actually be considered life-saving.

Val
02-15-2007, 11:15 AM
Jo, I see Rai's treatment differently than this. A child who appears to have ADD is by no means in a life threatening condition.
I understand that she was also diagnosed with bipolar disorder, and suicide is a big concern (dear lord, I know that all too well) but I don't think a toddler carries the same risk of suicide as an adult.

Onyx
02-15-2007, 10:34 PM
Bipolar disorder has the swings between manic and depressive (for some reason I think it's atleast 3 a year)

The number can vary quite a bit with the person, it really isn't quite a number like that.

At the same time, I do think that it should be very very rare that those meds are used in a child, And I would be very hesitant to even consider it. At the same time, I do have a friend whose 8yo was just finally diagnosed with BP, and that was after years of resistance on her part to have her child medicated, but things just got bad. Her daughter would flip out, hurt other people, get horribly depressed, all sorts of stuff, and finally she realized that they would have to treat it. She still doesn't like the idea, but she's tried all of the alternatives.

I think that is what is missing in the above case - you can't just jump to the conclusion that someone sufferers from this, esp when they are 2, and the other thing is, when someone, particularly a child, is being treated for BP, you have to keep an eye on them because of the way people can react to the meds. It bothers me that they apparently had been treating her with this since two - how much was the actively being monitored and adjusted? Argh.

Jo
02-15-2007, 10:44 PM
Jo, I see Rai's treatment differently than this. A child who appears to have ADD is by no means in a life threatening condition.
I understand that she was also diagnosed with bipolar disorder, and suicide is a big concern (dear lord, I know that all too well) but I don't think a toddler carries the same risk of suicide as an adult.


I fully agree that Rai's meds are totally different though interestingly they have found that some anti seizure meds also help with some psychiatric disorders as well. When these issue come up, the media tends to get up and arms about off label usage. I just think that usage needs to be used judiciously. I also think that people want a quick fix. Heck-I would love a quick fix...with no side effects to many issues. But the caveat is with no side effects. The side effects of using these type of meds on kids that age is such a dangerous unknown that the risks vs benefits should be seriously weighed.

On a personal level this quote from the article especially bothers me.
One preschool teacher said that at about 2 p.m. every day the girl came to life, “as if the medication Rebecca was on was wearing off,” according to the documents.


At that age, why would anybody think that is normal. Rai was on some serious meds that snowed the heck out of her. We had to do it to keep the seizure activity to a minimum for various reasons. I don't understand how this can be considered the norm day after day for a child that age by the doctor she had. But since I also don't understand how she could be diagnosed like she was, that isn't surprising.

Beka
02-16-2007, 02:02 AM
It disturbs me at age 2 they can label a child with something as dramatic as bipolar- i can't help but feel it must take alot of parental pushing of a weak doctor to attain that as the only thing i can see most would prescribe is parenting classes for parents to learn to deal with the mood swings that are part and parcel of the toddler years, medicating for something with no physical effects at that age does worry me alot.

Also i can not see what defense they have- it is one thing to give a child the prescribed dosage of a medicine but entirely different to give them more of it than prescribed

Kate
02-16-2007, 06:32 AM
So I'm sitting here right now trying to scrape my jaw off the floor. As has already been said, I can't begin to comprehend how anyone could give that kind of a diagnosis to a two year old, let alone begin to prescribe for it.

I'm sure I'm going to want to rant about this a bit more, but I think I might have to do that later when I've had a chance to get my head around it all.

Maleah
02-16-2007, 07:09 AM
It would be totally stretching it for me, but maybe.. just maybe the doctor took tons of time to Dx the little girl BP. Let's assume that they did.

Why the heck was she on so many meds?! What guidelines did this doctor use for the Rx? Surely these medications haven't been studied on children this young and surely there's very little if any information on the effects of these meds off label for a child this young!

Did the parents attend any classes or counciling before putting this child on the cocktail?

Why in the heck weren't they monitored more closely?

This is just insane. Poor little girl.

I think we need to start holding Drs and parents accountable for when children are harmed by parents taking the easy way out. I am not talking about meds that actually improve the child's quality of life or meds that are needed. But when a child is harmed it seems like everyone starts pointing fingers and no one is actually on the hook.

Okay, I am off my soapbox.

Val
02-16-2007, 09:25 AM
Oh- I just meant to be diagnosed, the guidlines for diagnoses where you have to meet, say 10 out of 13 of these problems to be daignosed lists a number of swings in any given year.

The number can vary quite a bit with the person, it really isn't quite a number like that.

gr8mommy
02-18-2007, 07:25 AM
I am always skeptical about news stories such as these, or any news stories for that matter, as I know firsthand how they can twist facts or leave them out. Also, as a former special education teacher I know that some children are very severely affected psychiatrically at a very young age, though it is against common practice to diagnose bipolar or schzophrenia much before age 9 or 10.

Depakote isn't a 'mood medication', it is an antiseizure medication. My goddaughter has been on it her entire life, and she is now 15. Clonidine is approved for use in children, and as it has the effect of interrupting impulses along some nerve pathways could conceivably be helpful in controlling a seizure disorder as well.

Seroquel is not approved for use in children, and I'd be questioning the prescribing doctor about using it in this case, as well as how he came about whatever diagnosis he gave the girl and who was consulted on the case. I'd wonder why the parents didn't seek a second opinion, and I'd also investigate whether she was enrolled in any sort of early intervention programs.